Unit

UNIT 7.5 Determination of Compound Binding to Plasma Proteins

  1. Natasha Dow

Published Online: 1 NOV 2002

DOI: 10.1002/0471141755.ph0705s18

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Dow, N. 2002. Determination of Compound Binding to Plasma Proteins. Current Protocols in Pharmacology. 7:7.5.

Author Information

  1. Ricerca LLC, Concord, Ohio

Publication History

  1. Published Online: 1 NOV 2002
  2. Published Print: SEP 2002

This is not the most recent version of the article. View current version (1 OCT 2006)

Abstract

The pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasma proteins. Consequently, the determination of the plasma protein binding of a compound is essential during drug development and is increasingly required during lead prioritization. This unit describes the use of ultrafiltration and equilibrium dialysis techniques for determination of plasma protein binding. The pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasm