UNIT 7.6 Determination of the Stability of Drugs in Plasma

  1. David A. Hartman

Published Online: 1 FEB 2003

DOI: 10.1002/0471141755.ph0706s19

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Hartman, D. A. 2003. Determination of the Stability of Drugs in Plasma. Current Protocols in Pharmacology. 19:7.6:7.6.1–7.6.8.

Author Information

  1. Ricerca LLC, Concord, Ohio

Publication History

  1. Published Online: 1 FEB 2003
  2. Published Print: DEC 2002


In order for a drug to be effective, enough of the active form must reach the target to elicit the desired effect. The first-pass effect for drugs taken orally is well known but the metabolism of drugs in plasma must also be considered during the drug discovery and development process. For instance, hydrolysis of a compound by plasma enzymes can significantly alter the bioavailability of the active compound. This unit describes methods for the determination of the stability of compounds in plasma.