UNIT 7.6 Determination of the Stability of Drugs in Plasma
Published Online: 1 FEB 2003
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Hartman, D. A. 2003. Determination of the Stability of Drugs in Plasma. Current Protocols in Pharmacology. 19:7.6:7.6.1–7.6.8.
- Published Online: 1 FEB 2003
- Published Print: DEC 2002
In order for a drug to be effective, enough of the active form must reach the target to elicit the desired effect. The first-pass effect for drugs taken orally is well known but the metabolism of drugs in plasma must also be considered during the drug discovery and development process. For instance, hydrolysis of a compound by plasma enzymes can significantly alter the bioavailability of the active compound. This unit describes methods for the determination of the stability of compounds in plasma.