Unit

UNIT 9.7 Overview on the Use of Therapeutic Antibodies in Drug Discovery

  1. Michael Roguska,
  2. Zehra Kaymakcalan,
  3. Jochen Salfeld

Published Online: 1 JAN 2005

DOI: 10.1002/0471141755.ph0907s27

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Roguska, M., Kaymakcalan, Z. and Salfeld, J. 2005. Overview on the Use of Therapeutic Antibodies in Drug Discovery. Current Protocols in Pharmacology. 27:9.7:9.7.1–9.7.17.

Author Information

  1. Abbott Bioresearch Center, Worcester, Massachusetts

Publication History

  1. Published Online: 1 JAN 2005
  2. Published Print: DEC 2004

Abstract

The number of therapeutic antibodies approved by regulatory agencies as novel drugs and the number of antibodies in development has increased significantly. The modular nature of antibody structure has enabled researchers to more predictably design therapeutic antibodies by choosing appropriate functional features most appropriate for a given antibody target and clinical indication. Advances in recombinant antibody technologies have allowed the routine generation of antibodies that can satisfy stringent drug design criteria, such as low immunogenicity, high affinity, target specificity, and commercially viable manufacturing methods. Engineering design opportunities exist for both the variable and the constant regions that encompass, in addition to antigen specificity and affinity, effector functions that mediate immune complex clearance or pharmacokinetics. These are discussed in the context of relevant in vivo and in vitro technologies, such as human IgG transgenic mice, phage display, and biologics manufacturing. Finally, therapeutic antibodies are compared with traditional drugs with respect to target class, selectivity, route of administration, intellectual property issues, and lead discovery and optimization.

Keywords:

  • therapeutic antibodies;
  • antibody generation;
  • antibody engineering