Unit

UNIT 9.16 Parallel Chemistry in the 21st Century

  1. Alan Long

Published Online: 1 SEP 2012

DOI: 10.1002/0471141755.ph0916s58

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Long, A. 2012. Parallel Chemistry in the 21st Century. Current Protocols in Pharmacology. 58:9.16:9.16.1–9.16.16.

Author Information

  1. SCYNEXIS, Research Triangle Park, North Carolina

Publication History

  1. Published Online: 1 SEP 2012

Abstract

The tool chest of techniques, methodologies, and equipment for conducting parallel chemistry is larger than ever before. Improvements in the laboratory and developments in computational chemistry have enabled compound library design at the desks of medicinal chemists. This unit includes a brief background in combinatorial/parallel synthesis chemistry, along with a discussion of evolving technologies for both solid- and solution-phase chemistry. In addition, there are discussions on designing compound libraries, acquisition/procurement of compounds and/or reagents, the chemistry and equipment used for chemical production, purification, sample handling, and data analysis. Curr. Protoc. Pharmacol. 58:9.16.1-9.16.16. © 2012 by John Wiley & Sons, Inc.

Keywords:

  • parallel chemistry;
  • combinatorial chemistry;
  • fluorous chemistry;
  • multi-component reactions;
  • library design;
  • laboratory equipment;
  • DOS;
  • diversity oriented synthesis