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UNIT 10.2 Models of Inflammation: Measuring Gastrointestinal Ulceration in the Rat

  1. Phyllis E. Whiteley,
  2. Stacie A. Dalrymple

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph1002s00

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Whiteley, P. E. and Dalrymple, S. A. 2001. Models of Inflammation: Measuring Gastrointestinal Ulceration in the Rat. Current Protocols in Pharmacology. 00:10.2:10.2.1–10.2.4.

Author Information

  1. Roche Bioscience, Palo Alto, California

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAR 1998

Abstract

In rats, nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin induce gastrointestinal ulcerations. This unit describes a procedure to elicit and measure indomethacin-induced gastrointestinal lesions. This approach can be used to test for gastrointestinal side effects of potential anti-inflammatory and other agents.