UNIT 10.4 Place Preference Test in Rodents

  1. Sylvain Roux1,
  2. Christelle Froger1,
  3. Roger D. Porsolt1,
  4. Olga Valverde2,
  5. Rafael Maldonado2

Published Online: 1 FEB 2003

DOI: 10.1002/0471141755.ph1004s19

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Roux, S., Froger, C., Porsolt, R. D., Valverde, O. and Maldonado, R. 2003. Place Preference Test in Rodents. Current Protocols in Pharmacology. 19:10.4:10.4.1–10.4.14.

Author Information

  1. 1

    Porsolt and Partners Pharmacology, Boulogne Billancourt, France

  2. 2

    Laboratori de Neurofarmacologia University Pompeu Fabra, Barcelona, Spain

Publication History

  1. Published Online: 1 FEB 2003
  2. Published Print: DEC 2002


Conditioned place preference is a behavioral model currently used to measure the rewarding properties induced by the administration of a drug. In this paradigm, the rewarding properties of a compound are associated with the particular characteristics of a given environment. Advantages of this test are the absence of any instrumental learning and the possibility of evaluating reinforcing effects in the absence of the test substance. Due to the recent availability of multiple lines of genetically modified mice, this unit has been updated to include procedures for testing place preference in both rats and mice. Details are also provided for evaluating drug effects using this procedure.