UNIT 10.5 Models of Neurological Disease (Substance Abuse): Self-Administration in Monkeys

  1. Donna M. Platt1,
  2. Galen Carey2,
  3. Roger D. Spealman1

Published Online: 1 MAR 2012

DOI: 10.1002/0471141755.ph1005s56

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Platt, D. M., Carey, G. and Spealman, R. D. 2012. Models of Neurological Disease (Substance Abuse): Self-Administration in Monkeys. Current Protocols in Pharmacology. 56:10.5:10.5.1–10.5.17.

Author Information

  1. 1

    New England Primate Research Center/Harvard Medical School, Southborough, Massachusetts

  2. 2

    Ironwood Pharmaceuticals, Cambridge, Massachusetts

Publication History

  1. Published Online: 1 MAR 2012
  2. Published Print: MAR 2012


Drug self-administration is a procedure in which a subject performs a specified response that results in the delivery of a drug injection. This procedure is viewed as a relevant model for the study of human drug-taking behavior. Drug self-administration in primates has several characteristics that resemble drug-taking behavior in humans, and agents commonly abused by humans also generally maintain self-administration behavior in monkeys. Self-administration procedures allow for the study of a variety of drug properties. For instance, they can be used to investigate the abuse potential of new compounds and to study the effects of candidate medications for the treatment of drug addiction. These procedures can also be employed for examining drug reinforcement mechanisms. Described in this unit are procedures for studying intravenous drug self-administration in large primates, such as rhesus macaques, and smaller primates, such as squirrel monkeys. Curr. Protoc. Pharmacol. 56:10.5.1-10.5.17. © 2012 by John Wiley & Sons, Inc.


  • self-administration;
  • monkey;
  • intravenous