UNIT 11.1 Overview of Electrophysiological Techniques

  1. Alan D. Wickenden

Published Online: 3 MAR 2014

DOI: 10.1002/0471141755.ph1101s64

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Wickenden, A. D. 2014. Overview of Electrophysiological Techniques. Current Protocols in Pharmacology. 11:11.1:11.1.1–11.1.17.

Author Information

  1. Janssen R&D, San Diego, California

Publication History

  1. Published Online: 3 MAR 2014


This unit provides an overview of the principal electrophysiological techniques commonly used for the study of ionic currents and the ion channels that mediate them. These techniques include electroencephalograms (EEGs), electrocardiograms (ECGs), single- and multiunit extracellular recording, multielectrode arrays, transepithelial recording, impedance measurements, and current-clamp, voltage-clamp, patch-clamp, and lipid bilayer recording. The unit also discusses recent advances in high-throughput, automated electrophysiological techniques for drug discovery and the use of stem cells as a tissue source. Curr. Protoc. Pharmacol. 64:11.1.1-11.1.17. © 2014 by John Wiley & Sons, Inc.


  • extracellular recording;
  • intracellular recording;
  • patch clamp;
  • planar patch clamp;
  • drug discovery;
  • stem cells