UNIT 11.7 Overview of Electrophysiological Characterization of Neuronal Nicotinic Acetylcholine Receptors
Published Online: 1 FEB 2004
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Bertrand, S. and Bertrand, D. 2004. Overview of Electrophysiological Characterization of Neuronal Nicotinic Acetylcholine Receptors. Current Protocols in Pharmacology. 23:11.7:11.7.1–11.7.24.
- Published Online: 1 FEB 2004
- Published Print: DEC 2003
Electrophysiology is one of the best tools to characterize ligand-gated channels such as neuronal nicotinic acetylcholine receptors. In this unit, the properties of these receptors are discussed along with approaches for how they can be characterized. Special emphasis is given to agonist and antagonist profiles as well as allosteric effectors that offer alternative possibilities in drug discovery.
- neuronal nicotinic acetylcholine receptors;
- ligand-gated channels;
- allosteric modulation