Unit

UNIT 11.7 Overview of Electrophysiological Characterization of Neuronal Nicotinic Acetylcholine Receptors

  1. Sonia Bertrand,
  2. Daniel Bertrand

Published Online: 1 FEB 2004

DOI: 10.1002/0471141755.ph1107s23

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Bertrand, S. and Bertrand, D. 2004. Overview of Electrophysiological Characterization of Neuronal Nicotinic Acetylcholine Receptors. Current Protocols in Pharmacology. 23:11.7:11.7.1–11.7.24.

Author Information

  1. Centre Médical Universitaire, Geneva, Switzerland

Publication History

  1. Published Online: 1 FEB 2004
  2. Published Print: DEC 2003

Abstract

Electrophysiology is one of the best tools to characterize ligand-gated channels such as neuronal nicotinic acetylcholine receptors. In this unit, the properties of these receptors are discussed along with approaches for how they can be characterized. Special emphasis is given to agonist and antagonist profiles as well as allosteric effectors that offer alternative possibilities in drug discovery.

Keywords:

  • neuronal nicotinic acetylcholine receptors;
  • ligand-gated channels;
  • electrophysiology;
  • characterization;
  • agonist;
  • antagonist;
  • allosteric modulation