Unit

UNIT 12.7 Measurement of VLA-4/CS-1 and VLA-4/VCAM Adhesion Inhibition

  1. Christopher Mehlin

Published Online: 1 MAY 2004

DOI: 10.1002/0471141755.ph1207s24

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Mehlin, C. 2004. Measurement of VLA-4/CS-1 and VLA-4/VCAM Adhesion Inhibition. Current Protocols in Pharmacology. 24:12.7:12.7.1–12.7.8.

Author Information

  1. University of Washington, Seattle, Washington

Publication History

  1. Published Online: 1 MAY 2004
  2. Published Print: MAR 2004

Abstract

Cell adhesion, a critical early step in the inflammatory process, has increasingly become the target of drug discovery efforts. Described in this unit are techniques for measuring inhibitors of VLA-4-mediated adhesion to either VCAM or the connecting segment (CS-1) of fibronectin.

Keywords:

  • VLA-4;
  • VCAM;
  • CS-1;
  • cell adhesion;
  • inflammation