Unit

UNIT 14.1 Murine and Canine Models of Appendicular Osteosarcoma

  1. Timothy M. Fan

Published Online: 1 JUN 2007

DOI: 10.1002/0471141755.ph1401s37

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Fan, T. M. 2007. Murine and Canine Models of Appendicular Osteosarcoma. Current Protocols in Pharmacology. 37:14.1:14.1.1–14.1.16.

Author Information

  1. University of Illinois at Urbana-Champaign, Urbana, Illinois

Publication History

  1. Published Online: 1 JUN 2007
  2. Published Print: JUN 2007

Abstract

Appendicular osteosarcoma (OSA) is a primary bone sarcoma affecting humans during their second decade of life. Despite aggressive surgical and chemotherapeutic interventions, 30% of patients will experience progressive metastatic disease within 5 years of diagnosis. Understanding the biology of pediatric OSA and potential targets for therapeutic development remains an area of focus for both basic scientists and clinical oncologists. The identification and study of relevant comparative tumor models in mice and canines may allow for a better understanding of OSA biology, and permit the rapid investigation of novel therapeutic strategies for managing this metastatic bone sarcoma. This unit provides a protocol for using an orthotopic, syngeneic murine model of appendicular OSA as an investigative tool for the study of OSA biology. Additionally, the comparative relevance of spontaneously occurring appendicular OSA in canines for the study of pediatric bone sarcomas is discussed.

Keywords:

  • comparative tumor model;
  • spontaneous disease;
  • translational research;
  • primary bone sarcoma;
  • experimental therapeutics