UNIT 14.7 Application of Radiotherapy and Chemotherapy Protocols to Pre-Clinical Tumor Models

  1. Randy Burd1,
  2. Phyllis Wachsberger2

Published Online: 1 SEP 2007

DOI: 10.1002/0471141755.ph1407s38

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Burd, R. and Wachsberger, P. 2007. Application of Radiotherapy and Chemotherapy Protocols to Pre-Clinical Tumor Models. Current Protocols in Pharmacology. 38:14.7:14.7.1–14.7.24.

Author Information

  1. 1

    University of Arizona, Tucson, Arizona

  2. 2

    Thomas Jefferson University, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 SEP 2007
  2. Published Print: SEP 2007


This unit (1) provides background into understanding how agents that target specific molecules or receptors (molecular-targeted agents), in particular, agents affecting the tumor vasculature (perivasculature network in tumors), interact with and modify radiation therapy; (2) details factors affecting interpretation of results in murine tumor model experiments utilizing radiation therapy and drug combinations; and (3) provides specific protocols for the application of radiation therapy, both alone and in combination with chemotherapy and/or molecular-targeted agents. Curr. Protoc. Pharmacol. 38:14.7.1-14.7.24. © 2007 by John Wiley & Sons, Inc.


  • chemotherapy;
  • radiation therapy;
  • tumor models;
  • tumor hypoxia;
  • tumor growth delay;
  • preclinical