UNIT 14.8 Preclinical Chemotherapeutic Tumor Models of Common Childhood Cancers: Solid Tumors, Acute Lymphoblastic Leukemia, and Disseminated Neuroblastoma
Published Online: 1 DEC 2007
Copyright © 2007 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Morton, C. L., Papa, R. A., Lock, R. B. and Houghton, P. J. 2007. Preclinical Chemotherapeutic Tumor Models of Common Childhood Cancers: Solid Tumors, Acute Lymphoblastic Leukemia, and Disseminated Neuroblastoma. Current Protocols in Pharmacology. 39:14.8:14.8.1–14.8.21.
- Published Online: 1 DEC 2007
- Published Print: DEC 2007
This unit presents three models used in the Pediatric Preclinical Testing Program of the National Cancer Institute (NCI) for preclinical testing of new chemical entities (NCEs), along with appropriate methods for data analysis. The first is the classical subcutaneous xenograft model used for many solid tumors, the second is the disseminated human leukemia model established by Lock and colleagues, and the third is a disseminated model of neuroblastoma that recapitulates many of the characteristics of advanced clinical disease. Curr. Protoc. Pharmacol. 39:14.8.1-14.8.21. © 2007 by John Wiley & Sons, Inc.
- preclinical testing;
- developmental therapeutics;
- xenograft models