Unit

UNIT 14.8 Preclinical Chemotherapeutic Tumor Models of Common Childhood Cancers: Solid Tumors, Acute Lymphoblastic Leukemia, and Disseminated Neuroblastoma

  1. Christopher L. Morton1,
  2. Rachel A. Papa2,
  3. Richard B. Lock2,
  4. Peter J. Houghton1

Published Online: 1 DEC 2007

DOI: 10.1002/0471141755.ph1408s39

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Morton, C. L., Papa, R. A., Lock, R. B. and Houghton, P. J. 2007. Preclinical Chemotherapeutic Tumor Models of Common Childhood Cancers: Solid Tumors, Acute Lymphoblastic Leukemia, and Disseminated Neuroblastoma. Current Protocols in Pharmacology. 39:14.8:14.8.1–14.8.21.

Author Information

  1. 1

    St. Jude Children's Research Hospital, Memphis, Tennessee

  2. 2

    Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia

Publication History

  1. Published Online: 1 DEC 2007
  2. Published Print: DEC 2007

Abstract

This unit presents three models used in the Pediatric Preclinical Testing Program of the National Cancer Institute (NCI) for preclinical testing of new chemical entities (NCEs), along with appropriate methods for data analysis. The first is the classical subcutaneous xenograft model used for many solid tumors, the second is the disseminated human leukemia model established by Lock and colleagues, and the third is a disseminated model of neuroblastoma that recapitulates many of the characteristics of advanced clinical disease. Curr. Protoc. Pharmacol. 39:14.8.1-14.8.21. © 2007 by John Wiley & Sons, Inc.

Keywords:

  • preclinical testing;
  • developmental therapeutics;
  • xenograft models