Unit

UNIT 14.18 Preclinical Orthotopic and Intracardiac Injection Models of Human Breast Cancer Metastasis to Bone and Their Use in Drug Discovery

  1. Ellen Scepansky1,
  2. Robert Goldstein2,
  3. Michael Rosenblatt3

Published Online: 1 MAR 2011

DOI: 10.1002/0471141755.ph1418s52

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Scepansky, E., Goldstein, R. and Rosenblatt, M. 2011. Preclinical Orthotopic and Intracardiac Injection Models of Human Breast Cancer Metastasis to Bone and Their Use in Drug Discovery. Current Protocols in Pharmacology. 52:14.18:14.18.1–14.18.23.

Author Information

  1. 1

    Tufts Medical Center, Division of Hematology/Oncology, Boston, Massachusetts

  2. 2

    Tufts University School of Medicine and Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts

  3. 3

    Tufts University School of Medicine, Department of Physiology and Medicine, Boston, Massachusetts

Publication History

  1. Published Online: 1 MAR 2011
  2. Published Print: MAR 2011

Abstract

Breast cancer is the most common malignancy in women, with the development of distant metastases rendering the condition incurable. Relatively little is known about the factors governing the progression from primary tumor to metastasis, in part because of the difficulty in modeling what is a complex series of events. Detailed in this unit are descriptions of two murine models of breast cancer metastasis to bone that can be used to screen the effectiveness of new chemical entities on this disease process. Curr. Protoc. Pharmacol. 52:14.18.1-14.18.23. © 2011 by John Wiley & Sons, Inc.

Keywords:

  • breast cancer;
  • bone metastasis;
  • orthotopic model;
  • intracardiac model;
  • bioluminescent imaging