UNIT 14.29 Overview of Genetically Engineered Mouse Models of Colorectal Carcinoma to Enable Translational Biology and Drug Development
Published Online: 16 JUN 2014
Copyright © 2013 John Wiley & Sons, Inc. All rights reserved.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Roper, J., Martin, E. S. and Hung, K. E. 2014. Overview of Genetically Engineered Mouse Models of Colorectal Carcinoma to Enable Translational Biology and Drug Development. Current Protocols in Pharmacology. 65:14.29:14.29.1–14.29.10.
- Published Online: 16 JUN 2014
Preclinical models for colorectal cancer (CRC) are critical for translational biology and drug development studies to characterize and treat this condition. Mouse models of human cancer are particularly popular because of their relatively low cost, short life span, and ease of use. Genetically engineered mouse models (GEMMs) of CRC are engineered from germline or somatic modification of critical tumor suppressor genes and/or oncogenes that drive mutations in human disease. Detailed in this overview are the salient features of several useful colorectal cancer GEMMs and their value as tools for translational biology and preclinical drug development. Curr. Protoc. Pharmacol. 65:14.29.1-14.29.10. © 2014 by John Wiley & Sons, Inc.
- cancer models;
- genetically engineered mouse models;
- colorectal cancer;
- orthotopic transplantation