APPENDIX 1B Receptor Nomenclature Guidelines
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Williams, M. 2001. Receptor Nomenclature Guidelines. Current Protocols in Pharmacology. 6:1B:A.1B.1–A.1B.64.
- Published Online: 1 MAY 2001
- Published Print: SEP 1999
Receptors are typically characterized via two distinct approaches: (1) the identification and pharmacological characterization of a receptor-mediated response using classical pharmacological and/or radioligand approaches in tissues and animal models using selective agonist and antagonist ligands, and; (2) the cloning and expression of proteins with structural homology to known receptors, the function of which is subsequently established by studying the structure activity relationship (SAR) of receptor-mediated responses. An additional means to characterize receptors proceeded, and evolved, with the structural approach, namely classification in terms of signal transduction mechanisms. The International Union of Pharmacology (IUPHAR) created guidelines and selected working groups for each receptor family to establish a common nomenclature system. Reports from those groups that have reached some degree of consensus have been summarized in this appendix.