UNIT 1.13 Quantified Assessment of Terminal Density and Innervation

  1. David I. Finkelstein,
  2. Davor Stanic,
  3. Clare L. Parish,
  4. John Drago,
  5. Malcolm K. Horne

Published Online: 1 SEP 2004

DOI: 10.1002/0471142301.ns0113s27

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Finkelstein, D. I., Stanic, D., Parish, C. L., Drago, J. and Horne, M. K. 2004. Quantified Assessment of Terminal Density and Innervation. Current Protocols in Neuroscience. 27:1.13:1.13.1–1.13.16.

Author Information

  1. Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia

Publication History

  1. Published Online: 1 SEP 2004
  2. Published Print: APR 2004


Stereological methods allow for the determination of cell numbers, terminal densities, and, subsequently, the estimation of terminal arbor size within a given brain nucleus. This unit provides an explanation for determining the terminal arbor size of dopaminergic neurons of the nigrostriatal pathway in rodents. In contrast to previously used single-axon reconstructions, these stereological methods allow for quick and easy determination of terminal arbor size.


  • Stereology;
  • fractionator;
  • terminal density;
  • terminal arbor;
  • immunohistochemistry