UNIT 6.2 Principles of Signal Conditioning

  1. Alan Finkel1,
  2. Richard Bookman2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142301.ns0602s00

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Finkel, A. and Bookman, R. 2001. Principles of Signal Conditioning. Current Protocols in Neuroscience. 00:6.2:6.2.1–6.2.15.

Author Information

  1. 1

    Axon Instruments, Foster City, California

  2. 2

    University of Miami School of Medicine, Miami, Florida

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: SEP 1997


It is rare for biological, physiological, chemical, electrical, or physical signals to be measured in the appropriate format for recording and interpretation. Usually, a signal must be conditioned to optimize it for both of these functions. This overview describes the fundamentals of signal filtering, how to prepare signals for A/D conversion, signal averaging to increase the signal-to-noise ratio, line frequency pickup (hum), peak-to-peak and rms noise measurements, blanking, audio monitoring, testing of electrodes and the common-mode rejection ratio.