UNIT 6.13 Synaptic Plasticity in the Hippocampal Slice Preparation

  1. Zuner A. Bortolotto,
  2. William W. Anderson,
  3. John T.R. Isaac,
  4. Graham L. Collingridge

Published Online: 1 NOV 2001

DOI: 10.1002/0471142301.ns0613s16

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Bortolotto, Z. A., Anderson, W. W., Isaac, J. T. and Collingridge, G. L. 2001. Synaptic Plasticity in the Hippocampal Slice Preparation. Current Protocols in Neuroscience. 16:6.13:6.13.1–6.13.23.

Author Information

  1. MRC Centre for Synaptic Plasticity, Bristol, United Kingdom

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: AUG 2001

This is not the most recent version of the article. View current version (1 JAN 2011)


Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain slice preparations.