UNIT 6.13 Synaptic Plasticity in the Hippocampal Slice Preparation

  1. Zuner A. Bortolotto1,
  2. Mascia Amici1,
  3. William W. Anderson1,
  4. John T.R. Isaac2,
  5. Graham L. Collingridge1,3

Published Online: 1 JAN 2011

DOI: 10.1002/0471142301.ns0613s54

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Bortolotto, Z. A., Amici, M., Anderson, W. W., Isaac, J. T. and Collingridge, G. L. 2011. Synaptic Plasticity in the Hippocampal Slice Preparation. Current Protocols in Neuroscience. 54:6.13:6.13.1–6.13.26.

Author Information

  1. 1

    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom

  2. 2

    Eli Lilly & Co., Lilly Research Centre, Windlesham, Surrey, United Kingdom

  3. 3

    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Korea

Publication History

  1. Published Online: 1 JAN 2011
  2. Published Print: JAN 2011


Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain slice preparations. Curr. Protoc. Neurosci. 54:6.13.1-6.13.26. © 2011 by John Wiley & Sons, Inc.


  • LTP;
  • LTD;
  • hippocampus;
  • synaptic plasticity;
  • glutamate receptors;
  • organotypic slice;
  • WinLTP