UNIT 7.16 Peripheral Type Benzodiazepine Binding Sites as a Tool for the Detection and Quantification of CNS Injury
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Benavides, J., Dubois, A. and Scatton, B. 2001. Peripheral Type Benzodiazepine Binding Sites as a Tool for the Detection and Quantification of CNS Injury. Current Protocols in Neuroscience. 9:7.16:7.16.1–7.16.10.
- Published Online: 1 MAY 2001
- Published Print: NOV 1999
The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.