Unit

UNIT 7.16 Peripheral Type Benzodiazepine Binding Sites as a Tool for the Detection and Quantification of CNS Injury

  1. Jesús Benavides,
  2. Alain Dubois,
  3. Bernard Scatton

Published Online: 1 MAY 2001

DOI: 10.1002/0471142301.ns0716s09

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Benavides, J., Dubois, A. and Scatton, B. 2001. Peripheral Type Benzodiazepine Binding Sites as a Tool for the Detection and Quantification of CNS Injury. Current Protocols in Neuroscience. 9:7.16:7.16.1–7.16.10.

Author Information

  1. Synthélabo Recherche, Bagneux Cédex, France

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: NOV 1999

Abstract

The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.