Unit

UNIT 8.6C Direct, Continuous Behavioral Analysis of Drug Action on Feeding

  1. Simon Goodson1,
  2. Jason Halford2,
  3. John Blundell3

Published Online: 1 NOV 2004

DOI: 10.1002/0471142301.ns0806cs29

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Goodson, S., Halford, J. and Blundell, J. 2004. Direct, Continuous Behavioral Analysis of Drug Action on Feeding. Current Protocols in Neuroscience. 29:8.6C:8.6C.1–8.6C.11.

Author Information

  1. 1

    University of Sheffield, Sheffield, United Kingdom

  2. 2

    University of Liverpool, Liverpool, United Kingdom

  3. 3

    University of Leeds, Leeds, United Kingdom

Publication History

  1. Published Online: 1 NOV 2004
  2. Published Print: OCT 2004

Abstract

Analysis of rodent feeding behavior during the study of anorectic drugs reveals that contextual variables such as type of food, drug, environment, and physiological state influence food intake. Temporal changes in behavior can signal the onset of a feeding modulation process, as is the case with anorectic drugs acting on distinct neurochemical mechanisms that change temporal behavioral profiles. Comparing the effects of anorectic agents in controlled animal assays can identify potential therapeutic drugs that may influence human eating behavior. This unit specifies the materials and procedures required for continuously monitoring the Behavioral Satiety Sequence, as well as a device for continuous, automatic measurement of the mass of food consumption by the animal during behavioral monitoring called the RUEMA (Rat Universal Eating Monitor Apparatus).