Unit

UNIT 8.10A Rodent Models of Depression: Forced Swimming and Tail Suspension Behavioral Despair Tests in Rats and Mice

  1. Roger D. Porsolt,
  2. Geneviève Brossard,
  3. Carine Hautbois,
  4. Sylvain Roux

Published Online: 1 MAY 2001

DOI: 10.1002/0471142301.ns0810as14

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Porsolt, R. D., Brossard, G., Hautbois, C. and Roux, S. 2001. Rodent Models of Depression: Forced Swimming and Tail Suspension Behavioral Despair Tests in Rats and Mice. Current Protocols in Neuroscience. 14:8.10A:8.10A.1–8.10A.10.

Author Information

  1. Porsolt and Partners Pharmacology, Boulogne-Billancourt, France

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: FEB 2001

This is not the most recent version of the article. View current version (1 APR 2011)

Abstract

Rodents forced to swim in a narrow space from which there is no escape will, after an initial period of vigorous activity, adopt a characteristic immobile posture, making only those movements necessary to keep their heads above the water. It was hypothesized that immobility reflected the animals' having learned that escape was impossible and their having given up hope. Immobility was therefore given the name “behavioral despair”. Immobility was subsequently found to be reduced by a wide range of clinically active antidepressant drugs. This simple behavioral procedure has since become a useful test for screening novel antidepressants in rats and is presented in this unit. An equivalent procedure in the mouse is also described along with a “dry” version of the test where immobility is induced simply by suspending the mouse by the tail.