Unit

UNIT 8.21D Behavioral Assessment of Hearing in Mice—Conditioned Suppression

  1. Henry E. Heffner,
  2. Gimseong Koay,
  3. Rickye S. Heffner

Published Online: 1 FEB 2006

DOI: 10.1002/0471142301.ns0821ds34

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Heffner, H. E., Koay, G. and Heffner, R. S. 2006. Behavioral Assessment of Hearing in Mice—Conditioned Suppression. Current Protocols in Neuroscience. 34:8.21D:8.21D.1–8.21D.15.

Author Information

  1. University of Toledo, Toledo, OH

Publication History

  1. Published Online: 1 FEB 2006
  2. Published Print: JAN 2006

Abstract

The method of conditioned suppression described in this unit involves training a thirsty mouse to make steady contact with a waterspout in order to receive a slow, but steady trickle of water and then pairing a sound with mild electric shock delivered through the spout. The mouse quickly learns to avoid the shock by breaking contact with the spout whenever it detects the sound. This suppression of drinking is then used to indicate that the animal detected the sound. Because it is a cognitively simple procedure, conditioned suppression can be used to determine the ability of brain-damaged and genetically altered as well as normal animals to detect and discriminate sounds.

Keywords:

  • audition;
  • hearing;
  • detection;
  • discrimination;
  • sound localization;
  • mice