UNIT 8.23 Fear Extinction in Rodents

  1. Chun-hui Chang,
  2. Ewelina Knapska,
  3. Caitlin A. Orsini,
  4. Christine A. Rabinak,
  5. Joshua M. Zimmerman,
  6. Stephen Maren

Published Online: 1 APR 2009

DOI: 10.1002/0471142301.ns0823s47

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Chang, C.-h., Knapska, E., Orsini, C. A., Rabinak, C. A., Zimmerman, J. M. and Maren, S. 2009. Fear Extinction in Rodents. Current Protocols in Neuroscience. 47:8.23:8.23.1–8.23.17.

Author Information

  1. University of Michigan, Ann Arbor, Michigan

Publication History

  1. Published Online: 1 APR 2009
  2. Published Print: APR 2009


Pavlovian conditioning paradigms have become important model systems for understanding the neuroscience of behavior. In particular, studies of the extinction of Pavlovian fear responses are yielding important information about the neural substrates of anxiety disorders, such as phobias and post-traumatic stress disorder (PTSD) in humans. These studies are germane to understanding the neural mechanisms underlying behavioral interventions that suppress fear, including exposure therapy in anxiety disorders. This unit describes detailed behavioral protocols for examining the nature and properties of fear extinction in laboratory rodents. Curr. Protoc. Neurosci. 47:8.23.1-8.23.17. © 2009 by John Wiley & Sons, Inc.


  • extinction;
  • fear;
  • rat;
  • anxiety;
  • phobia