UNIT 9.2 Traumatic Brain Injury in the Rat Using the Fluid-Percussion Model

  1. Geoffrey S.F. Ling,
  2. Eleanor Y. Lee,
  3. Audrey N. Kalehua

Published Online: 1 SEP 2004

DOI: 10.1002/0471142301.ns0902s28

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Ling, G. S., Lee, E. Y. and Kalehua, A. N. 2004. Traumatic Brain Injury in the Rat Using the Fluid-Percussion Model. Current Protocols in Neuroscience. 28:9.2:9.2.1–9.2.11.

Author Information

  1. Uniformed Services University of the Health Sciences, Bethesda, Maryland

Publication History

  1. Published Online: 1 SEP 2004
  2. Published Print: JUL 2004


Traumatic brain injury is a leading cause of death and disability, particularly among young adults. During closed head trauma, the injury process is initiated by the impact of the brain against the inner table of the calvarium. Subsequently, there is prompt initiation of a complex biochemical, cellular, and physiological injury cascade that may take days to complete. From a functional standpoint, this culminates in neurologic dysfunction and, if severe, death. This unit describes an impact-induced brain trauma model in rats which replicates nonpenetrating head injury. It does not model either penetrating or ischemic brain injuries.