UNIT 9.3 Preclinical Models of Hepatic Encephalopathy

  1. Anthony S. Basile1,
  2. Kevin Mullen2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142301.ns0903s08

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Basile, A. S. and Mullen, K. 2001. Preclinical Models of Hepatic Encephalopathy. Current Protocols in Neuroscience. 8:9.3:9.3.1–9.3.34.

Author Information

  1. 1

    Laboratory of Bio-Organic Chemistry, National Institute of Diabetes and Digestive & Kidney Diseases, NIH, Bethesda, Maryland

  2. 2

    Case Western Reserve University, Cleveland, Ohio

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: AUG 1999


Parkinson's disease is a neurodegenerative disease in which pigmented midbrain neurons progressively die producing a dopamine (DA) deficit in the striatum which manifests as an akinetic movement disorder. Experimentally induced striatal DA depletion in animals is a valid model of parkinsonism. The capacity of certain substances to damage catecholaminergic neurones has been used for a long time to produce DA deficiency in animals. This unit focuses on methods for inducing parkinsonism using the neurotoxins MPTP and 6-hydroxy dopamine and methods for evaluating the animals. Other models are briefly reviewed.