UNIT 9.6 Rodent Models of Focal Cerebral Ischemia

  1. Michael J. O'Neill1,
  2. James A. Clemens2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142301.ns0906s12

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

O'Neill, M. J. and Clemens, J. A. 2001. Rodent Models of Focal Cerebral Ischemia. Current Protocols in Neuroscience. 12:9.6:9.6.1–9.6.32.

Author Information

  1. 1

    Eli Lilly and Co., Windlesham, Surrey, United Kingdom

  2. 2

    Lilly Corporate Center, Indianapolis, Indiana

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: AUG 2000


This unit presents models that are both used to study ischemic mechanisms and to test for neuroprotective agents or agents that enhance recovery from stroke. The Tamura model is one of the best characterized focal ischemia models in which the middle cerebral artery is occluded by electrocoagulation. Also described is the intraluminal monofilament model, the spontaneously hypertensive rat (SHR), and the newer endothelin-1 model. The rationale behind the use of animal models, the various types of models and advantage and disadvantages of each model are presented.