UNIT 9.10 Overview of Rodent Models for Obesity Research

  1. Matthias Tschöp,
  2. Mark L. Heiman

Published Online: 1 FEB 2002

DOI: 10.1002/0471142301.ns0910s17

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Tschöp, M. and Heiman, M. L. 2002. Overview of Rodent Models for Obesity Research. Current Protocols in Neuroscience. 17:9.10:9.10.1–9.10.14.

Author Information

  1. Lilly Research Laboratories, Indianapolis, Indiana

Publication History

  1. Published Online: 1 FEB 2002
  2. Published Print: OCT 2001


Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (e.g., high-fat diet-induced obesity), spontaneous mutants (i.e., ob/ob mice), genetically engineered animals (e.g., mice with melanocortin receptor subtype-4 gene disruption (knock-out), or mechanical intervention (e.g., chemical lesion of the ventromedial hypothalamus). This unit reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.