UNIT 9.10 Overview of Rodent Models for Obesity Research
Published Online: 1 FEB 2002
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Tschöp, M. and Heiman, M. L. 2002. Overview of Rodent Models for Obesity Research. Current Protocols in Neuroscience. 17:9.10:9.10.1–9.10.14.
- Published Online: 1 FEB 2002
- Published Print: OCT 2001
Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (e.g., high-fat diet-induced obesity), spontaneous mutants (i.e., ob/ob mice), genetically engineered animals (e.g., mice with melanocortin receptor subtype-4 gene disruption (knock-out), or mechanical intervention (e.g., chemical lesion of the ventromedial hypothalamus). This unit reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.