UNIT 9.16 Inducing Photochemical Cortical Lesions in Rat Brain

  1. Marcelle Bergeron

Published Online: 1 JUL 2003

DOI: 10.1002/0471142301.ns0916s23

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Bergeron, M. 2003. Inducing Photochemical Cortical Lesions in Rat Brain. Current Protocols in Neuroscience. 23:9.16:9.16.1–9.16.18.

Author Information

  1. Lilly Research Laboratories, Indianapolis, Indiana

Publication History

  1. Published Online: 1 JUL 2003
  2. Published Print: APR 2003


In the rat photochemical cortical lesion model described in this unit, an intravascular photochemical reaction induces endothelial damage resulting in platelet aggregation, thrombosis, thrombotic response (secretion of factors by the platelets) and permanent cerebral vascular occlusion. Because thrombosis is produced in pial vessels, the resulting cortical infarct is generally smaller and more reproducible than in the models involving occlusion of the middle cerebral artery. The surgical procedures involved are limited, making this model generally easier to perform and less invasive than most other models of permanent focal ischemia that involve mechanical occlusion of major cerebral arteries.