Unit

UNIT 9.17 Measurement of Panic-Like Responses Following Intravenous Infusion of Sodium Lactate in Panic-Prone Rats

  1. Tammy J. Sajdyk,
  2. Stanley R. Keim,
  3. Shelley R. Thielen,
  4. Stephanie D. Fitz,
  5. Anantha Shekhar

Published Online: 1 NOV 2003

DOI: 10.1002/0471142301.ns0917s24

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Sajdyk, T. J., Keim, S. R., Thielen, S. R., Fitz, S. D. and Shekhar, A. 2003. Measurement of Panic-Like Responses Following Intravenous Infusion of Sodium Lactate in Panic-Prone Rats. Current Protocols in Neuroscience. 24:9.17:9.17.1–9.17.19.

Author Information

  1. Indiana University Medical Center, Indianapolis, Indiana

Publication History

  1. Published Online: 1 NOV 2003
  2. Published Print: JUL 2003

Abstract

This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.

Keywords:

  • Amygdala;
  • anxiety;
  • CRF;
  • GABA;
  • hypothalamus;
  • panic;
  • social interaction;
  • sodium lactate;
  • stress