UNIT 9.18 Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model
Published Online: 1 NOV 2004
Copyright © 2004 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Morrow, T. J. 2004. Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model. Current Protocols in Neuroscience. 29:9.18:9.18.1–9.18.11.
- Published Online: 1 NOV 2004
- Published Print: OCT 2004
Painful peripheral neuropathy is a common secondary complication of diabetes. The streptozotocin (STZ)-induced diabetic rat is the most commonly employed animal model used to study mechanisms of painful diabetic neuropathy and to evaluate potential therapies. A low dose STZ protocol is described for inducing experimental diabetes in the rat. Several behavioral assays are described, which are routinely used to assess different aspects of neuropathic pain in this animal model of diabetes mellitus, including mechanical allodynia and heat hyperalgesia.
- experimental type I diabetes mellitus;
- peripheral polyneuropathy;
- neuropathic pain