UNIT 9.18 Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model

  1. Thomas J. Morrow

Published Online: 1 NOV 2004

DOI: 10.1002/0471142301.ns0918s29

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Morrow, T. J. 2004. Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model. Current Protocols in Neuroscience. 29:9.18:9.18.1–9.18.11.

Author Information

  1. VA Medical Center, University of Michigan, Ann Arbor, Michigan

Publication History

  1. Published Online: 1 NOV 2004
  2. Published Print: OCT 2004


Painful peripheral neuropathy is a common secondary complication of diabetes. The streptozotocin (STZ)-induced diabetic rat is the most commonly employed animal model used to study mechanisms of painful diabetic neuropathy and to evaluate potential therapies. A low dose STZ protocol is described for inducing experimental diabetes in the rat. Several behavioral assays are described, which are routinely used to assess different aspects of neuropathic pain in this animal model of diabetes mellitus, including mechanical allodynia and heat hyperalgesia.


  • streptozotocin;
  • STZ;
  • experimental type I diabetes mellitus;
  • peripheral polyneuropathy;
  • neuropathic pain