UNIT 9.20 Chronic Intravenous Drug Self-Administration in Rats and Mice
Published Online: 1 AUG 2005
Copyright © 2005 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Thomsen, M. and Caine, S. B. 2005. Chronic Intravenous Drug Self-Administration in Rats and Mice. Current Protocols in Neuroscience. 32:9.20:9.20.1–9.20.40.
- Published Online: 1 AUG 2005
- Published Print: JUL 2005
Chronic intravenous drug self-administration in rodents is a useful procedure for predicting the abuse liability of novel drugs in humans, for evaluating candidate treatments for drug abuse and dependence, and for studying the biological basis of addiction. This unit focuses on recent technical innovations for conducting long-term studies of i.v. drug self-administration behavior in healthy, freely moving rats and mice. Included are protocols for construction, implantation, and maintenance of chronic indwelling jugular catheters, commentary on critical parameters, a troubleshooting guide, and anticipated results.
- drug abuse;
- animal model