Unit

UNIT 9.26 Overview of Mouse Assays of Ethanol Intoxication

  1. John C. Crabbe1,
  2. Andy J. Cameron1,
  3. Elizabeth Munn2,
  4. Mark Bunning2,
  5. Douglas Wahlsten2

Published Online: 1 JAN 2008

DOI: 10.1002/0471142301.ns0926s42

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Crabbe, J. C., Cameron, A. J., Munn, E., Bunning, M. and Wahlsten, D. 2008. Overview of Mouse Assays of Ethanol Intoxication. Current Protocols in Neuroscience. 42:9.26:9.26.1–9.26.19.

Author Information

  1. 1

    Portland VA Medical Center, Portland, Oregon

  2. 2

    University of Windsor, Windsor, Ontario, Canada

Publication History

  1. Published Online: 1 JAN 2008
  2. Published Print: JAN 2008

Abstract

There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct “ethanol intoxication” completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several. Curr. Protoc. Neurosci. 42:9.26.1-9.26.19. © 2008 by John Wiley & Sons, Inc.

Keywords:

  • ethanol;
  • intoxication;
  • ataxia;
  • mouse;
  • inbred strains;
  • genetics;
  • test batteries