UNIT 9.26 Overview of Mouse Assays of Ethanol Intoxication
Published Online: 1 JAN 2008
Copyright © 2007 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Crabbe, J. C., Cameron, A. J., Munn, E., Bunning, M. and Wahlsten, D. 2008. Overview of Mouse Assays of Ethanol Intoxication. Current Protocols in Neuroscience. 42:9.26:9.26.1–9.26.19.
- Published Online: 1 JAN 2008
- Published Print: JAN 2008
There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct “ethanol intoxication” completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several. Curr. Protoc. Neurosci. 42:9.26.1-9.26.19. © 2008 by John Wiley & Sons, Inc.
- inbred strains;
- test batteries