UNIT 9.27 Schedule-Induced Polydipsia: A Rat Model of Obsessive-Compulsive Disorder
Published Online: 1 APR 2008
Copyright © 2008 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Platt, B., Beyer, C. E., Schechter, L. E. and Rosenzweig-Lipson, S. 2008. Schedule-Induced Polydipsia: A Rat Model of Obsessive-Compulsive Disorder. Current Protocols in Neuroscience. 43:9.27.1–9.27.8.
- Published Online: 1 APR 2008
- Published Print: APR 2008
Obsessive-compulsive disorder (OCD) is difficult to model in animals due to the involvement of both mental (obsessions) and physical (compulsions) symptoms. Due to limitations of using animals to evaluate obsessions, OCD models are limited to evaluation of the compulsive and repetitive behaviors of animals. Of these, models of adjunctive behaviors offer the most value in regard to predicting efficacy of anti-OCD drugs in the clinic. Adjunctive behaviors are those that are maintained indirectly by the variables that control another behavior, rather than directly by their own typical controlling variables. Schedule-induced polydipsia (SIP) is an adjunctive model in which rats exhibit exaggerated drinking behavior (polydipsia) when presented with food pellets under a fixed-time schedule. The polydipsic response is an excessive manifestation of a normal behavior (drinking), providing face validity to the model. Furthermore, clinically effective drugs for the treatment of OCD decrease SIP. This protocol describes a rat SIP model of OCD and provides preclinical data for drugs that decrease polydipsia and are clinically effective in the treatment of OCD. Curr. Protoc. Neurosci. 43:9.27.1-9.27.8. © 2008 by John Wiley & Sons, Inc.
Keywords: obsessive-compulsive disorder; polydipsia; adjunctive drinking; in vivo; rat