UNIT 9.31 An Animal Model of Premenstrual Dysphoric Disorder Sensitive to Antidepressants

  1. Tomasz Schneider,
  2. Piotr Popik

Published Online: 1 JAN 2009

DOI: 10.1002/0471142301.ns0931s46

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Schneider, T. and Popik, P. 2009. An Animal Model of Premenstrual Dysphoric Disorder Sensitive to Antidepressants. Current Protocols in Neuroscience. 46:9.31:9.31.1–9.31.10.

Author Information

  1. Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

Publication History

  1. Published Online: 1 JAN 2009
  2. Published Print: JAN 2009


Premenstrual dysphoric disorder (PMDD) is characterized by the recurrence of a cluster of physical and negative mood symptoms, especially irritability, appearing when estrogen and progesterone levels decrease during the late luteal phase of the menstrual cycle. This unit describes a new animal model of PMDD that shows differentiation between female rats expressing and not expressing ovarian cycle–dependent irritability measured by the behavior of burying harmless objects. Burying behavior is enhanced in a subgroup of female rats at metestrus and decreased at the proestrus phase of the estrous cycle. Increased marble burying at metestrus does not habituate and can be reversed by acute treatment with several antidepressants, which mimic the pharmacology of PMDD in humans. This model may be used to study the neuroendocrine mechanisms triggering premenstrual irritability, and the mode of action of antidepressants used for the treatment of PMDD. Curr. Protoc. Neurosci. 46:9.31.1-9.31.10. © 2009 by John Wiley & Sons, Inc.


  • animal model;
  • irritability;
  • marble-burying test;
  • premenstrual dysphoric disorder;
  • antidepressants