UNIT 9.34 Drug-Induced Sexual Dysfunction in Rats
Published Online: 1 OCT 2010
Copyright © 2010 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Chan, J. S., Waldinger, M. D., Olivier, B. and Oosting, R. S. 2010. Drug-Induced Sexual Dysfunction in Rats. Current Protocols in Neuroscience. 53:9.34:9.34.1–9.34.11.
- Published Online: 1 OCT 2010
- Published Print: OCT 2010
This unit describes the testing of sexual behaviors of male Wistar rats. The described test enables the detection of stimulatory and inhibitory profiles of compounds. The test includes four training sessions to reach a stable sexual performance, followed by acute and/or chronic administration of drugs. The main quantifiable sexual behaviors are number of mounts (no vaginal penetration), intromissions (vaginal penetration), and ejaculations. By comparing the test compound to reference compound(s), sexual (side) effects can be determined. Curr. Protoc. Neurosci. 53:9.34.1-9.34.11. © 2010 by John Wiley & Sons, Inc.
- sexual behavior;