UNIT 9.34 Drug-Induced Sexual Dysfunction in Rats

  1. Johnny S.W. Chan1,
  2. Marcel D. Waldinger1,2,
  3. Berend Olivier1,3,
  4. Ronald. S. Oosting1

Published Online: 1 OCT 2010

DOI: 10.1002/0471142301.ns0934s53

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Chan, J. S., Waldinger, M. D., Olivier, B. and Oosting, R. S. 2010. Drug-Induced Sexual Dysfunction in Rats. Current Protocols in Neuroscience. 53:9.34:9.34.1–9.34.11.

Author Information

  1. 1

    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

  2. 2

    Department of Psychiatry and Neurosexology, Haga Hospital Leyenburg, The Hague, The Netherlands

  3. 3

    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

Publication History

  1. Published Online: 1 OCT 2010
  2. Published Print: OCT 2010


This unit describes the testing of sexual behaviors of male Wistar rats. The described test enables the detection of stimulatory and inhibitory profiles of compounds. The test includes four training sessions to reach a stable sexual performance, followed by acute and/or chronic administration of drugs. The main quantifiable sexual behaviors are number of mounts (no vaginal penetration), intromissions (vaginal penetration), and ejaculations. By comparing the test compound to reference compound(s), sexual (side) effects can be determined. Curr. Protoc. Neurosci. 53:9.34.1-9.34.11. © 2010 by John Wiley & Sons, Inc.


  • sexual behavior;
  • ejaculation;
  • rats;
  • SSRI;
  • dysfunction