Unit

UNIT 9.39 Prime-, Stress-, and Cue-Induced Reinstatement of Extinguished Drug-Reinforced Responding in Rats: Cocaine as the Prototypical Drug of Abuse

  1. Patrick M. Beardsley,
  2. Keith L. Shelton

Published Online: 1 OCT 2012

DOI: 10.1002/0471142301.ns0939s61

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Beardsley, P. M. and Shelton, K. L. 2012. Prime-, Stress-, and Cue-Induced Reinstatement of Extinguished Drug-Reinforced Responding in Rats: Cocaine as the Prototypical Drug of Abuse. Current Protocols in Neuroscience. 61:9.39:9.39.1–9.39.40.

Author Information

  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia

Publication History

  1. Published Online: 1 OCT 2012

Abstract

This unit describes the testing of rats in prime-, footshock-, and cue-induced reinstatement procedures. Evaluating rats in these procedures enables the assessment of treatments on behavior thought to model drug relapse precipitated by re-contact with an abused drug (prime-induced), induced by stress (footshock-induced), or by stimuli previously associated with drug administration (cue-induced). For instance, levels of reinstatement under the effects of test compound administration could be compared to levels under vehicle administration to help identify potential treatments for drug relapse, or reinstatement levels of different rat strains could be compared to identify potential genetic determinants of perseverative drug-seeking behavior. Cocaine is used as a prototypical drug of abuse, and relapse to its use serves as the model in this unit, but other self-administered drugs could readily be substituted with little modification to the procedures. Curr. Protoc. Neurosci. 61:9.39.1-9.39.40. © 2012 by John Wiley & Sons, Inc.

Keywords:

  • drug relapse;
  • drug abuse;
  • cocaine