Unit

UNIT 9.47 Rodent Model of Activity-Based Anorexia

  1. Olaia Carrera1,
  2. Ángela Fraga1,
  3. Ricardo Pellón2,
  4. Emilio Gutiérrez1,3

Published Online: 10 APR 2014

DOI: 10.1002/0471142301.ns0947s67

Current Protocols in Neuroscience

Current Protocols in Neuroscience

How to Cite

Carrera, O., Fraga, Á., Pellón, R. and Gutiérrez, E. 2014. Rodent Model of Activity-Based Anorexia. Current Protocols in Neuroscience. 67:9.47:9.47.1–9.47.11.

Author Information

  1. 1

    Unidade Venres Clinicos, Universidad de Santiago de Compostela, Galicia, Spain

  2. 2

    Departamento de Psicología Básica I, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Madrid, Spain

  3. 3

    Departamento de Psicología Clínica y Psicobiología, Universidad de Santiago de Compostela, Galicia, Spain

Publication History

  1. Published Online: 10 APR 2014

Abstract

Activity-based anorexia (ABA) consists of a procedure that involves the simultaneous exposure of animals to a restricted feeding schedule, while free access is allowed to an activity wheel. Under these conditions, animals show a progressive increase in wheel running, a reduced efficiency in food intake to compensate for their increased activity, and a severe progression of weight loss. Due to the parallelism with the clinical manifestations of anorexia nervosa including increased activity, reduced food intake and severe weight loss, the ABA procedure has been proposed as the best analog of human anorexia nervosa (AN). Thus, ABA research could both allow a better understanding of the mechanisms underlying AN and generate useful leads for treatment development in AN. Curr. Protoc. Neurosci. 67:9.47.1-9.47.11. © 2014 by John Wiley & Sons, Inc.

Keywords:

  • activity-based anorexia;
  • physical activity;
  • food restriction;
  • self-starvation;
  • anorexia nervosa