UNIT 9.47 Rodent Model of Activity-Based Anorexia
Published Online: 10 APR 2014
Copyright © 2013 John Wiley & Sons, Inc. All rights reserved.
Lab Protocol Title
Current Protocols in Neuroscience
How to Cite
Carrera, O., Fraga, Á., Pellón, R. and Gutiérrez, E. 2014. Rodent Model of Activity-Based Anorexia. Current Protocols in Neuroscience. 67:9.47:9.47.1–9.47.11.
- Published Online: 10 APR 2014
Activity-based anorexia (ABA) consists of a procedure that involves the simultaneous exposure of animals to a restricted feeding schedule, while free access is allowed to an activity wheel. Under these conditions, animals show a progressive increase in wheel running, a reduced efficiency in food intake to compensate for their increased activity, and a severe progression of weight loss. Due to the parallelism with the clinical manifestations of anorexia nervosa including increased activity, reduced food intake and severe weight loss, the ABA procedure has been proposed as the best analog of human anorexia nervosa (AN). Thus, ABA research could both allow a better understanding of the mechanisms underlying AN and generate useful leads for treatment development in AN. Curr. Protoc. Neurosci. 67:9.47.1-9.47.11. © 2014 by John Wiley & Sons, Inc.
- activity-based anorexia;
- physical activity;
- food restriction;
- anorexia nervosa