UNIT 1.7 Synthesis of Protected 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides
Published Online: 1 NOV 2002
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Elzagheid, M. I., Viazovkina, E. and Damha, M. J. 2002. Synthesis of Protected 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides. Current Protocols in Nucleic Acid Chemistry. 10:1.7:1.7.1–1.7.19.
- Published Online: 1 NOV 2002
- Published Print: SEP 2002
This unit describes in detail the preparation of protected 2'-deoxy-2'-fluoroarabinonucleosides. These building blocks are required for the synthesis of 2'-deoxy-2'-fluoroarabinonucleic acid (2'F-ANA), an oligonucleotide analog exhibiting very promising antisense properties. The preparation of phosphoramidites from these building blocks and the synthesis of 2'F-ANA are described elsewhere in the manual.