Unit

UNIT 1.7 Synthesis of Protected 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides

  1. Mohamed I. Elzagheid,
  2. Ekaterina Viazovkina,
  3. Masad J. Damha

Published Online: 1 NOV 2002

DOI: 10.1002/0471142700.nc0107s10

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Elzagheid, M. I., Viazovkina, E. and Damha, M. J. 2002. Synthesis of Protected 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides. Current Protocols in Nucleic Acid Chemistry. 10:1.7:1.7.1–1.7.19.

Author Information

  1. McGill University, Montreal, Canada

Publication History

  1. Published Online: 1 NOV 2002
  2. Published Print: SEP 2002

Abstract

This unit describes in detail the preparation of protected 2'-deoxy-2'-fluoroarabinonucleosides. These building blocks are required for the synthesis of 2'-deoxy-2'-fluoroarabinonucleic acid (2'F-ANA), an oligonucleotide analog exhibiting very promising antisense properties. The preparation of phosphoramidites from these building blocks and the synthesis of 2'F-ANA are described elsewhere in the manual.