UNIT 1.10 Synthesis and Properties of 7-Substituted 7-Deazapurine (Pyrrolo[2,3-d]pyrimidine) 2′-Deoxyribonucleosides
Published Online: 1 JUL 2005
Copyright © 2005 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Seela, F. and Peng, X. 2005. Synthesis and Properties of 7-Substituted 7-Deazapurine (Pyrrolo[2,3-d]pyrimidine) 2′-Deoxyribonucleosides. Current Protocols in Nucleic Acid Chemistry. 21:1.10:1.10.1–1.10.20.
- Published Online: 1 JUL 2005
- Published Print: JUN 2005
7-Substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2′-deoxyribonucleosides are synthesized by stereoselective nucleobase anion glycosylation. The introduction of a halogen at C7 is performed regioselectively either on the nucleobase or on the nucleoside. The pKa values of a series of 7-deazapurine 2′-deoxyribonucleosides are provided, and fluorescence properties are also discussed.
- nucleobase anion glycosylation;
- regioselective halogenation;
- pKa values;