UNIT 1.12 Synthesis of Fluorinated Nucleosides
Published Online: 1 JUL 2006
Copyright © 2006 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Katayama, S., Takamatsu, S., Hirose, N., Izawa, K. and Maruyama, T. 2006. Synthesis of Fluorinated Nucleosides. Current Protocols in Nucleic Acid Chemistry. 25:1.12:1.12.1–1.12.30.
- Published Online: 1 JUL 2006
- Published Print: JUN 2006
Two practical synthetic approaches to the production of lodenosine [FddA, 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine] via 6-chloropurine riboside or 6-chloropurine 3′-deoxyriboside are described. The reaction sequence contains new fluorination methods and new applications of radical reduction. The reagents and reaction conditions of each step have been carefully selected to ensure robustness and safety.
- adenine 2′-deoxy-2′-fluoroarabinoside;
- 6-chloropurine 3′-deoxyriboside;
- radical reduction