UNIT 1.13 Synthesis of Ribonucleosides by Condensation Using Trimethylsilyl Triflate
Published Online: 1 JAN 2007
Copyright © 2006 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Vorbrüggen, H., Lagoja, I. M. and Herdewijn, P. 2007. Synthesis of Ribonucleosides by Condensation Using Trimethylsilyl Triflate. Current Protocols in Nucleic Acid Chemistry. 27:1.13:1.13.1–1.13.16.
- Published Online: 1 JAN 2007
- Published Print: DEC 2006
This unit describes, in detail, the optimized condition for the synthesis of nucleosides making use of the trimethysilyl triflate–mediated silyl-Hilbert-Johnson synthesis. This unit focuses on the mechanistic understanding of this universal and conveniently applicable method.
- nucleoside synthesis;
- Lewis acid catalysis;
- Vorbrüggen condensation