Unit

UNIT 2.6 Deoxyribo- and Ribonucleoside H-Phosphonates

  1. Jacek Stawinski1,
  2. Roger Strömberg2

Published Online: 1 MAY 2001

DOI: 10.1002/0471142700.nc0206s04

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Stawinski, J. and Strömberg, R. 2001. Deoxyribo- and Ribonucleoside H-Phosphonates. Current Protocols in Nucleic Acid Chemistry. 4:2.6:2.6.1–2.6.15.

Author Information

  1. 1

    Stockholm University, Stockholm, Sweden

  2. 2

    Karolinska Institutet, Stockholm, Sweden

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: APR 2001

Abstract

Most methods for preparing H-phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products. Taken together, they provide an arsenal of phosphonylation prodecures that it compatible with most common protecting groups.