Unit

UNIT 3.1 Solid-Phase Supports for Oligonucleotide Synthesis

  1. Andrei P. Guzaev

Published Online: 1 JUN 2013

DOI: 10.1002/0471142700.nc0301s53

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Guzaev, A. P. 2013. Solid-Phase Supports for Oligonucleotide Synthesis. Current Protocols in Nucleic Acid Chemistry. 53:3.1:3.1.1–3.1.60.

Author Information

  1. AM Chemicals LLC, Oceanside, California

Publication History

  1. Published Online: 1 JUN 2013

Abstract

This unit attempts to provide a reasonably complete inventory of over 280 solid supports available to oligonucleotide chemists for preparation of natural and 3′-modified oligonucleotides. Emphasis is placed on non-nucleosidic solid supports. The relationship between the structural features of linkers and their behavior in oligonucleotide synthesis and deprotection is discussed wherever the relevant observations are available. Curr. Protoc. Nucleic Acid Chem. 53:3.1.1-3.1.60. © 2013 by John Wiley & Sons, Inc.

Keywords:

  • nucleic acid chemistry;
  • oligonucleotides;
  • solid-phase synthesis;
  • molecular biology