Unit

UNIT 4.1 A Brief History, Status, and Perspective of Modified Oligonucleotides for Chemotherapeutic Applications

  1. P. Dan Cook

Published Online: 1 MAY 2001

DOI: 10.1002/0471142700.nc0401s00

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Cook, P. D. 2001. A Brief History, Status, and Perspective of Modified Oligonucleotides for Chemotherapeutic Applications. Current Protocols in Nucleic Acid Chemistry. 00:4.1:4.1.1–4.1.17.

Author Information

  1. Isis Pharmaceuticals, Carlsbad, California

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: FEB 2000

This is not the most recent version of the article. View current version (1 SEP 2011)

Abstract

The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of modified oligonucleotides that are complementary to specific nucleotide sequences in mRNA targets. Such modified oligonucleotides can be used to disrupt the flow of genetic information from transcribed mRNAs to proteins. This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. This overview reports recent advances in the application of oligonucleotides as drug candidates, describes the relationship between oligonucleotide modifications and their therapeutic profiles, and provides general guidelines for enhancing oligonucleotide drug properties.