UNIT 4.1 A Brief History, Status, and Perspective of Modified Oligonucleotides for Chemotherapeutic Applications
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Cook, P. D. 2001. A Brief History, Status, and Perspective of Modified Oligonucleotides for Chemotherapeutic Applications. Current Protocols in Nucleic Acid Chemistry. 00:4.1:4.1.1–4.1.17.
- Published Online: 1 MAY 2001
- Published Print: FEB 2000
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The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of modified oligonucleotides that are complementary to specific nucleotide sequences in mRNA targets. Such modified oligonucleotides can be used to disrupt the flow of genetic information from transcribed mRNAs to proteins. This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. This overview reports recent advances in the application of oligonucleotides as drug candidates, describes the relationship between oligonucleotide modifications and their therapeutic profiles, and provides general guidelines for enhancing oligonucleotide drug properties.