UNIT 14.3 Synthesis of β-L-2′-Deoxythymidine (L-dT)
Published Online: 1 APR 2006
Copyright © 2006 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Pierra, C., Dukhan, D., Gosselin, G. and Sommadossi, J.-P. 2006. Synthesis of β-L-2′-Deoxythymidine (L-dT). Current Protocols in Nucleic Acid Chemistry. 24:14.3:14.3.1–14.3.9.
- Published Online: 1 APR 2006
- Published Print: MAR 2006
The “unnatural” l-nucleoside β-l-2′-deoxythymidine (L-dT) is a potent, specific, and selective inhibitor of the replication of hepatitis B virus (HBV), which is currently in Phase III clinical trials. This unit describes, in detail, a semi-large-scale synthesis of l-dT. This convenient methodology produces l-dT in six steps starting with l-ribose and ending with a satisfactory overall yield of l-dT, and may be applied to other 2′-deoxynucleosides, incorporating different heterocyclic bases.
- anti-HBV agent;
- semi-large-scale synthesis;
- deoxygenation reaction