UNIT 14.8 One-Flask Synthesis of Cyclic Diguanosine Monophosphate (c-di-GMP)
Published Online: 1 MAR 2012
Copyright © 2012 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Gaffney, B. L. and Jones, R. A. 2012. One-Flask Synthesis of Cyclic Diguanosine Monophosphate (c-di-GMP). Current Protocols in Nucleic Acid Chemistry. 48:14.8:14.8.1–14.8.7.
- Published Online: 1 MAR 2012
- Published Print: MAR 2012
The bacterial signaling molecule, cyclic diguanosine monophosphate (c-di-GMP), plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here will facilitate these efforts. Curr. Protoc. Nucleic Acid Chem. 48:14.8.1-14.8.7. © 2012 by John Wiley & Sons, Inc.
- bacterial signaling;
- chemical synthesis