UNIT 17.2 Overview of Formation of G-Quadruplex Structures

  1. Yuta Sannohe1,
  2. Hiroshi Sugiyama1,2

Published Online: 1 MAR 2010

DOI: 10.1002/0471142700.nc1702s40

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Sannohe, Y. and Sugiyama, H. 2010. Overview of Formation of G-Quadruplex Structures. Current Protocols in Nucleic Acid Chemistry. 40:17.2:17.2.1–17.2.17.

Author Information

  1. 1

    Kyoto University, Kyoto, Japan

  2. 2

    Japan Science and Technology Corporation (CREST), Tokyo, Japan

Publication History

  1. Published Online: 1 MAR 2010
  2. Published Print: MAR 2010


There are many structures that can be adopted by nucleic acids other than the Watson-Crick duplex. In particular, a noncanonical four-stranded topology, called a G-quadruplex, is of great interest because of its roles in key biological processes such as the maintenance of telomeres and regulation of gene transcription. This review describes the condition for forming the G-quadruplex structure, G-quadruplex-forming sequences, and methods for studying the structures. Curr. Protoc. Nucleic Acid Chem. 40:17.2.1-17.2.17. © 2010 by John Wiley & Sons, Inc.


  • DNA structure;
  • quadruplex-forming sequences;
  • methods;
  • conditions