UNIT 17.2 Overview of Formation of G-Quadruplex Structures
Published Online: 1 MAR 2010
Copyright © 2010 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Sannohe, Y. and Sugiyama, H. 2010. Overview of Formation of G-Quadruplex Structures. Current Protocols in Nucleic Acid Chemistry. 40:17.2:17.2.1–17.2.17.
- Published Online: 1 MAR 2010
- Published Print: MAR 2010
There are many structures that can be adopted by nucleic acids other than the Watson-Crick duplex. In particular, a noncanonical four-stranded topology, called a G-quadruplex, is of great interest because of its roles in key biological processes such as the maintenance of telomeres and regulation of gene transcription. This review describes the condition for forming the G-quadruplex structure, G-quadruplex-forming sequences, and methods for studying the structures. Curr. Protoc. Nucleic Acid Chem. 40:17.2.1-17.2.17. © 2010 by John Wiley & Sons, Inc.
- DNA structure;
- quadruplex-forming sequences;