UNIT 17.6 Crystallography of DNA and RNA G-Quadruplex Nucleic Acids and Their Ligand Complexes
Published Online: 1 SEP 2012
Copyright © 2012 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Nucleic Acid Chemistry
How to Cite
Campbell, N., Collie, G. W. and Neidle, S. 2012. Crystallography of DNA and RNA G-Quadruplex Nucleic Acids and Their Ligand Complexes. Current Protocols in Nucleic Acid Chemistry. 50:17.6:17.6.1–17.6.22.
- Published Online: 1 SEP 2012
Quadruplexes are higher-order structures formed by natural guanine-rich nucleic acid sequences. They may play a role in gene regulation and in telomere function. This article focuses on the crystallization of quadruplexes and their complexes with small-molecule ligands. Protocols for successful crystallization, as used in the author's laboratory, are described in detail. Curr. Protoc. Nucleic Acid Chem. 50:17.6.1-17.6.22. © 2012 by John Wiley & Sons, Inc.
- nucleic acids;
- small molecules;