Unit

UNIT 17.6 Crystallography of DNA and RNA G-Quadruplex Nucleic Acids and Their Ligand Complexes

  1. Nancy Campbell,
  2. Gavin W. Collie,
  3. Stephen Neidle

Published Online: 1 SEP 2012

DOI: 10.1002/0471142700.nc1706s50

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

How to Cite

Campbell, N., Collie, G. W. and Neidle, S. 2012. Crystallography of DNA and RNA G-Quadruplex Nucleic Acids and Their Ligand Complexes. Current Protocols in Nucleic Acid Chemistry. 50:17.6:17.6.1–17.6.22.

Author Information

  1. Cancer Research UK Biomolecular Structure Group, The UCL School of Pharmacy, London, United Kingdom

Publication History

  1. Published Online: 1 SEP 2012

Abstract

Quadruplexes are higher-order structures formed by natural guanine-rich nucleic acid sequences. They may play a role in gene regulation and in telomere function. This article focuses on the crystallization of quadruplexes and their complexes with small-molecule ligands. Protocols for successful crystallization, as used in the author's laboratory, are described in detail. Curr. Protoc. Nucleic Acid Chem. 50:17.6.1-17.6.22. © 2012 by John Wiley & Sons, Inc.

Keywords:

  • crystallography;
  • crystallization;
  • quadruplex;
  • nucleic acids;
  • small molecules;
  • complex